Histopathologic Findings in Large for Gestational Age Placentas and Correlation With CD15 Immunohistochemistry.

IF 1.3 4区 医学 Q3 PATHOLOGY
Pediatric and Developmental Pathology Pub Date : 2023-09-01 Epub Date: 2023-08-20 DOI:10.1177/10935266231191965
Ansa Mehreen, Sunitha Suresh, Alexa A Freedman, Linda M Ernst
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引用次数: 0

Abstract

Background: The histopathology and CD15 expression in large for gestational age (LGA) placentas is not well-documented.

Methods: To analyze this, we utilized 2 separate cohorts of placentas from singleton term deliveries. LGA and appropriate for gestational age (AGA) placentas were compared for major histopathologies including acute and chronic inflammation, maternal and fetal vascular malperfusion, delayed villous maturation (DVM), and villous hypervascularity/chorangiosis. We also examined CD15 immunohistochemistry in LGA and AGA placentas. Stained slides were reviewed blinded to the placental weight. Five random 20× fields were scored semi-quantitatively for CD15 staining of villous capillaries on a scale of 0 to 5 (0 = 0%, 1 = 1%-5%, 2 = 5%-25%, 3 = 25%-50%, 4 = 50%-75%, and 5 = >75%).

Results: In 1 cohort, 1238 LGA and 7908 AGA placentas were identified. Patients with LGA placentas were significantly more likely to have higher birthweight babies, obesity, hypertensive disorders, pre-gestational, and gestational diabetes. Also, LGA placentas had a higher prevalence of fetal vascular malperfusion, DVM, and villous chorangiosis. In other cohort of 75 LGA placentas and 73 AGA controls, the average score of CD15 staining in villous capillaries was significantly higher amongst LGA placentas.

Conclusion: We conclude that LGA placentas have increased expression of CD15 in villous capillary endothelium and higher prevalence of FVM, DVM, and villous chorangiosis than AGA placentas.

大胎龄胎盘的组织病理学发现及其与CD15免疫组织化学的相关性。
背景:大胎龄(LGA)胎盘的组织病理学和CD15表达并没有很好的文献记载。方法:为了分析这一点,我们使用了来自单胎足月分娩的2个独立队列的胎盘。比较LGA和适合胎龄(AGA)胎盘的主要组织病理学,包括急性和慢性炎症、母体和胎儿血管灌注不良、绒毛成熟延迟(DVM)和绒毛血管增生/绒毛膜病。我们还检测了LGA和AGA胎盘的CD15免疫组织化学。不考虑胎盘重量对染色玻片进行盲法检查。随机选取5个20×场对绒毛毛细血管CD15染色进行半定量评分,评分范围为0 ~ 5(0 = 0%,1 = 1% ~ 5%,2 = 5% ~ 25%,3 = 25% ~ 50%,4 = 50% ~ 75%,5 = >75%)。结果:在1个队列中,鉴定出1238例LGA和7908例AGA胎盘。LGA胎盘的患者更有可能有更高的出生体重、肥胖、高血压疾病、孕前和妊娠糖尿病。此外,LGA胎盘的胎儿血管灌注不良、DVM和绒毛绒毛膜病的患病率更高。在另一组75例LGA胎盘和73例AGA对照中,LGA胎盘绒毛毛细血管CD15染色的平均评分显著高于LGA胎盘。结论:与AGA胎盘相比,LGA胎盘绒毛毛细血管内皮CD15表达增加,FVM、DVM和绒毛绒毛膜病患病率更高。
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来源期刊
CiteScore
3.70
自引率
5.30%
发文量
59
审稿时长
6-12 weeks
期刊介绍: The Journal covers the spectrum of disorders of early development (including embryology, placentology, and teratology), gestational and perinatal diseases, and all diseases of childhood. Studies may be in any field of experimental, anatomic, or clinical pathology, including molecular pathology. Case reports are published only if they provide new insights into disease mechanisms or new information.
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