Non-pharmacologic interventions for improving cancer-related fatigue (CRF): A systematic review of systematic reviews and pooled meta-analysis

IF 3 3区医学 Q2 ONCOLOGY

Seminars in oncology Pub Date : 2023-02-01 DOI:10.1053/j.seminoncol.2023.03.004

Silvia Belloni , Cristina Arrigoni , Irene Baroni , Gianluca Conte , Federica Dellafiore , Greta Ghizzardi , Arianna Magon , Giulia Villa , Rosario Caruso

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引用次数: 0

Abstract

Introduction

Literature encloses numerous systematic reviews (SRs) on nonpharmacologic interventions for improving cancer-related fatigue (CRF). The effect of these interventions remains controversial, and the available SRs have not been synthesized yet. We conducted a systematic synthesis of SRs and meta-analysis to determine the effect of nonpharmacologic interventions on CRF in adults.

Material and methods

We systematically searched 4 databases. The effect sizes (standard mean difference) were quantitatively pooled using a random-effects model. Chi-squared (Q) and I-square statistics (I²) tested the heterogeneity.

Results

We selected 28 SRs, including 35 eligible meta-analyses. The pooled effect size (standard mean difference, 95% CI) was -0.67 (-1.16, -0.18). The subgroup analysis by types of interventions showed a significant effect in all the investigated approaches (complementary integrative medicine, physical exercise, self-management/e-health interventions).

Conclusions

There is evidence that nonpharmacologic interventions are associated with CRF reduction. Future research should focus on testing these interventions on specific population clusters and trajectories.

Prospero registration

CRD42020194258.

查看原文本刊更多论文

改善癌症相关疲劳（CRF）的非药物干预：系统综述和汇总荟萃分析的系统综述

引言文献包括许多关于改善癌症相关疲劳（CRF）的非药物干预措施的系统综述（SR）。这些干预措施的效果仍然存在争议，可用的SRs尚未综合。我们对SRs和荟萃分析进行了系统综合，以确定非药物干预对成人CRF的影响。材料和方法我们系统地检索了4个数据库。使用随机效应模型对效应大小（标准平均差）进行定量汇总。卡方（Q）和I平方统计量（I²）检验了异质性。结果我们选择了28个SR，包括35个符合条件的荟萃分析。合并效应大小（标准平均差，95%CI）为-0.67（-1.16，-0.18）。按干预类型进行的亚组分析显示，所有研究方法（补充综合医学、体育锻炼、自我管理/电子健康干预）都有显著效果。结论有证据表明，非药物干预与CRF降低有关。未来的研究应侧重于在特定人群集群和轨迹上测试这些干预措施。Prospero注册CRD42020194258。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in oncology 医学-肿瘤学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

104 days

期刊介绍： Seminars in Oncology brings you current, authoritative, and practical reviews of developments in the etiology, diagnosis and management of cancer. Each issue examines topics of clinical importance, with an emphasis on providing both the basic knowledge needed to better understand a topic as well as evidence-based opinions from leaders in the field. Seminars in Oncology also seeks to be a venue for sharing a diversity of opinions including those that might be considered "outside the box". We welcome a healthy and respectful exchange of opinions and urge you to approach us with your insights as well as suggestions of topics that you deem worthy of coverage. By helping the reader understand the basic biology and the therapy of cancer as they learn the nuances from experts, all in a journal that encourages the exchange of ideas we aim to help move the treatment of cancer forward.