Ramadan fasting model exerts hepatoprotective, anti-obesity, and anti-hyperlipidemic effects in an experimentally-induced nonalcoholic fatty liver in rats.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Abeer A Alasmari, Abdulrahman S Al-Khalifah, Ahmed S BaHammam, Noura M S Alshiban, Ahmad T Almnaizel, Hesham S Alodah, Maha H Alhussain
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Abstract

Background: The epidemic of nonalcoholic fatty liver disease (NAFLD) and its metabolic effects present a serious public health concern. We hypothesized that the Ramadan fasting model (RFM), which involves fasting from dawn to dusk for a month, could provide potential therapeutic benefits and mitigate NAFLD. Accordingly, we aimed to validate this hypothesis using obese male rats.

Methods: Rats were split into two groups (n = 24 per group), and they were given either a standard (S) or high-fat diet (HFD) for 12 weeks. During the last four weeks of the study period, both S- and HFD-fed rats were subdivided into eight groups to assess the effect of RFM with/without training (T) or glucose administration (G) on the lipid profile, liver enzymes, and liver structure (n = 6/group).

Results: The HFD+RFM group exhibited a significantly lower final body weight than that in the HFDC group. Serum cholesterol, low-density lipoprotein, and triglyceride levels were significantly lower in the HFD+RFM, HFD+RFM+T, and HFD+RFM+G groups than those in the HFDC group. Compared with the HFDC group, all groups had improved serum high-density lipoprotein levels. Furthermore, HFD groups subjected to RFM had reduced serum levels of aspartate transaminase and alanine transaminase compared with those of the HFD-fed group. Moreover, the liver histology improved in rats subjected to RFM compared with that of HFD-fed rats, which exhibited macro- and micro-fat droplet accumulation.

Conclusion: RFM can induce positive metabolic changes and improve alterations associated with NAFLD, including weight gain, lipid profile, liver enzymes, and hepatic steatosis.

斋月禁食模型对实验性非酒精性脂肪肝大鼠具有肝保护、抗肥胖和抗高脂血症的作用。
背景:非酒精性脂肪性肝病(NAFLD)的流行及其代谢影响是一个严重的公共卫生问题。我们假设斋月禁食模式(RFM),包括从黎明到黄昏禁食一个月,可以提供潜在的治疗益处并减轻NAFLD。因此,我们的目的是用肥胖的雄性大鼠来验证这一假设。方法:将大鼠分为两组(每组24只),分别给予标准(S)和高脂(HFD)饮食12周。在研究期间的最后四周,将S-和hfd喂养的大鼠再分为8组,以评估RFM加/不加训练(T)或葡萄糖给药(G)对脂质谱、肝酶和肝脏结构的影响(n = 6/组)。结果:HFD+RFM组的最终体重明显低于HFDC组。HFD+RFM、HFD+RFM+T和HFD+RFM+G组血清胆固醇、低密度脂蛋白和甘油三酯水平均显著低于HFDC组。与HFDC组比较,各组血清高密度脂蛋白水平均有提高。此外,与饲料饲喂HFD组相比,饲料饲喂RFM的HFD组血清天冬氨酸转氨酶和丙氨酸转氨酶水平降低。此外,与饲喂hfd的大鼠相比,RFM大鼠肝脏组织学改善,出现宏观和微观脂肪滴积累。结论:RFM可以诱导积极的代谢变化,改善NAFLD相关的改变,包括体重增加、脂质谱、肝酶和肝脂肪变性。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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