Glasgow prognostic score as an outcome predictor for patients initiating hemodialysis.

IF 1.5 4区医学 Q3 HEMATOLOGY

Therapeutic Apheresis and Dialysis Pub Date : 2024-02-01 Epub Date: 2023-08-19 DOI:10.1111/1744-9987.14057

Gabriel Ștefan, Adrian Zugravu, Simona Stancu

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引用次数: 0

Abstract

Introduction: This retrospective study examined the relationship between the Glasgow Prognostic Score (GPS) at hemodialysis (HD) initiation and overall/cardiovascular mortality.

Methods: A total of 264 patients starting HD between 2014 and 2015 at a single center were studied. Follow-up persisted until therapy change, death, or study end (December 31, 2021), with a median of 6.8 years.

Results: Patients with a higher GPS more frequently had emergent HD initiation and showed increased eGFR at initiation. During follow-up, 60% of patients died, with cardiovascular disease being the leading cause. Univariate analysis revealed a significant difference in median survival time across GPS classes. Cox proportional hazard models confirmed a significant association between GPS and mortality.

Conclusions: We report a significant association between GPS at HD initiation and mortality. GPS may prove useful as a prognostic tool for identifying high-risk patients, underscoring the need for future research to validate these findings and explore the potential of GPS-based interventions.

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将格拉斯哥预后评分作为开始血液透析患者的预后预测指标。

简介：这项回顾性研究探讨了血液透析开始时的格拉斯哥预后评分（GPS）与总体/心血管死亡率之间的关系：这项回顾性研究探讨了血液透析（HD）开始时的格拉斯哥预后评分（GPS）与总死亡率/心血管死亡率之间的关系：研究对象为2014年至2015年期间在一个中心开始血液透析的264名患者。随访一直持续到治疗方案改变、死亡或研究结束（2021 年 12 月 31 日），中位随访时间为 6.8 年：结果：GPS较高的患者更常紧急开始接受血液透析治疗，并且在开始治疗时表现出更高的eGFR。随访期间，60%的患者死亡，心血管疾病是主要原因。单变量分析显示，不同GPS等级的中位生存时间存在显著差异。Cox比例危险模型证实，GPS与死亡率之间存在显著关联：我们报告了开始使用 HD 时的 GPS 与死亡率之间的显著关联。全球定位系统可能被证明是一种有用的预后工具，可用于识别高风险患者，这就强调了未来研究的必要性，以验证这些发现并探索基于全球定位系统的干预措施的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Apheresis and Dialysis 医学-泌尿学与肾脏学

CiteScore

3.00

自引率

10.50%

发文量

166

审稿时长

6-12 weeks

期刊介绍： Therapeutic Apheresis and Dialysis is the official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis and the Japanese Society for Dialysis Therapy. The Journal publishes original articles, editorial comments, review articles, case reports, meeting abstracts and Communications information on apheresis and dialysis technologies and treatments.