Botulinum Toxins and Zinc: From Theory to Practice-A Systematic Review.

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY

Clinical Neuropharmacology Pub Date : 2023-06-20 DOI:10.1097/WNF.0000000000000557

Farid Mallat, Jerome Kaikati, Elio Kechichian

引用次数: 0

Abstract

Objective The aims of this study were to determine whether zinc supplementation affects botulinum toxin's effect and longevity and to establish a transition from the molecular to the clinical aspect. Methods We conducted a systematic review in which we included all published studies on PubMed and Embase using the combination of the following terms: “zinc” AND (botox OR botulinum OR onabotulinumtoxinA OR abobotulinumtoxinA OR incobotulinumtoxinA). Results From the 260 yielded articles, 3 randomized control trials and 1 case report were retained. Three of them found a significant improvement with zinc supplementation in the toxin's effect and longevity. This was observed in neurological conditions and cosmetic uses. Conclusions Zinc supplementation could be an interesting asset in the potentialization of botulinum neurotoxin effect and longevity. Larger clinical trials and objective measurement tools should be used to further defining the role of zinc in maximizing botulinum neurotoxin effect.

查看原文本刊更多论文

肉毒杆菌毒素与锌:从理论到实践-系统综述。

目的:本研究的目的是确定锌补充剂是否影响肉毒毒素的作用和寿命，并建立从分子到临床方面的过渡。方法:我们进行了一项系统综述，纳入了PubMed和Embase上发表的所有研究，使用以下术语组合:“锌”和(肉毒杆菌毒素或肉毒杆菌毒素或肉毒杆菌毒素或肉毒杆菌毒素或肉毒杆菌毒素)。结果:260篇文献中，3篇随机对照试验和1篇病例报告被保留。其中三人发现补充锌对毒素的效果和寿命有显著改善。这在神经系统疾病和化妆品用途中观察到。结论:锌补充剂可能是肉毒杆菌神经毒素效应和长寿的潜在资产。需要更大规模的临床试验和客观的测量工具来进一步确定锌在最大限度地发挥肉毒杆菌神经毒素作用中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Neuropharmacology 医学-临床神经学

CiteScore

1.20

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Neuropharmacology is a peer-reviewed journal devoted to the pharmacology of the nervous system in its broadest sense. Coverage ranges from such basic aspects as mechanisms of action, structure-activity relationships, and drug metabolism and pharmacokinetics, to practical clinical problems such as drug interactions, drug toxicity, and therapy for specific syndromes and symptoms. The journal publishes original articles and brief reports, invited and submitted reviews, and letters to the editor. A regular feature is the Patient Management Series: in-depth case presentations with clinical questions and answers.