Incidence and Severity of Adverse Drug Reactions in Medical Intensive Care Unit.

IF 1.1 Q4 PHARMACOLOGY & PHARMACY
Sana Shaikh, Asawari Raut, Prajkta Jambhale, Shivkumar Iyer, Jignesh Shah
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引用次数: 0

Abstract

Background: Adverse drug reactions (ADRs) curtail patients' quality of life by virtue of increasing therapeutic complexity and rising multimorbidity. In India, the frequency of ADRs for individual drugs and their economic burdens are rarely evaluated. This study aimed at identifying the incidence and severity of ADRs leading to hospitalization (ADRA) and occurring during a hospital stay (ADRH).

Objective: The objective of this study is to evaluate the incidence the incidence and severity of ADRs in the ICU and their impact on the duration of hospitalization, along with the cost incurred to treat ADRs in the ICU.

Methods: Demographic, clinical, and pharmacological data on patients admitted to the ICU were collected, analyzed and evaluated for ADRs. According to the setting analyzed, a descriptive analysis of the reactions, suspected medicines, and associated factors was undertaken.

Results: A total of 208 patients were admitted to the ICU during the study period, of which ADRA contributed 9.1% of the incidence rate and 8.1% of ADRH in 36 patients. Males had a higher incidence of ADRs than females. Patients who had ADRs had a substantially longer length of stay than those who did not. Electrolyte disturbance was the most commonly found ADR. According to the Hartwig scale and WHO-causality scale, 88.9% were moderate, and 97.2% were possible ADRs, respectively.

Conclusion: In this study, a similar incidence rate of ADRA and ADRH was observed. The average cost for treating ADRA was higher than that for treating ADRH. As a result, identifying and preventing these reactions is critical, as they cause the patient greater suffering.

内科重症监护室药物不良反应的发生率和严重程度。
背景:药物不良反应(ADRs)因治疗的复杂性和多病症的增加而降低了患者的生活质量。在印度,对个别药物的不良反应频率及其经济负担很少进行评估。本研究旨在确定导致住院(ADRA)和住院期间发生(ADRH)的 ADR 的发生率和严重程度:本研究旨在评估重症监护室 ADR 的发生率和严重程度及其对住院时间的影响,以及治疗重症监护室 ADR 所产生的费用:方法:收集、分析和评估重症监护室住院患者的人口统计学、临床和药理学数据。根据分析的环境,对反应、可疑药物和相关因素进行了描述性分析:研究期间,重症监护室共收治了 208 名患者,其中 36 名患者的 ADRA 发生率为 9.1%,ADRH 发生率为 8.1%。男性的 ADR 发生率高于女性。出现 ADR 的患者的住院时间远远长于未出现 ADR 的患者。电解质紊乱是最常见的 ADR。根据哈特维格量表和世界卫生组织因果关系量表,88.9%为中度不良反应,97.2%为可能的不良反应:本研究观察到 ADRA 和 ADRH 的发生率相似。治疗 ADRA 的平均费用高于治疗 ADRH 的平均费用。因此,识别和预防这些反应至关重要,因为它们会给患者带来更大的痛苦。
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来源期刊
Current drug safety
Current drug safety PHARMACOLOGY & PHARMACY-
CiteScore
2.10
自引率
0.00%
发文量
112
期刊介绍: Current Drug Safety publishes frontier articles on all the latest advances on drug safety. The journal aims to publish the highest quality research articles, reviews and case reports in the field. Topics covered include: adverse effects of individual drugs and drug classes, management of adverse effects, pharmacovigilance and pharmacoepidemiology of new and existing drugs, post-marketing surveillance. The journal is essential reading for all researchers and clinicians involved in drug safety.
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