Study on the mechanism of curcumin in the treatment of periodontitis through network pharmacology and mole-cular docking.

Q3 Medicine

华西口腔医学杂志 Pub Date : 2023-04-01 DOI:10.7518/hxkq.2023.2022370

Jingmei Yang, Ziliang Zhou, Yafei Wu, Min Nie

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引用次数: 1

Abstract

Objectives: This study aims to explore the therapeutic targets of curcumin in periodontitis through network pharmacology and molecular docking technology.

Methods: Targets of curcumin and periodontitis were predicted by different databases, and the protein-protein interaction (PPI) network constructed by String revealed the interaction between curcumin and periodontitis. The key target genes were screened for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Molecular docking was performed to analyze the binding potential of curcumin to periodontitis.

Results: A total of 672 periodontitis-related disease targets and 107 curcumin-acting targets were obtained from the databases, and 20 key targets were screened. The GO and KEGG analyses of the 20 targets showed that curcumin might play a therapeutic role through the hypoxia-inducible factor (HIF)-1 and parathyroid hormone (PTH) signaling pathways. Molecular docking analysis showed that curcumin had good binding potential with multiple targets.

Conclusions: The potential key targets and molecular mechanisms of curcumin in treating periodontitis provide a theoretical basis for new drug development and clinical applications.

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通过网络药理学和分子对接研究姜黄素治疗牙周炎的作用机制。

目的:本研究旨在通过网络药理学和分子对接技术探索姜黄素治疗牙周炎的靶点。方法:利用不同的数据库预测姜黄素与牙周炎的作用靶点，并利用String构建蛋白-蛋白相互作用(PPI)网络揭示姜黄素与牙周炎的相互作用。筛选关键靶基因进行基因本体(GO)和京都基因与基因组百科全书(KEGG)分析。通过分子对接分析姜黄素对牙周炎的结合势。结果:从数据库中共获得牙周炎相关疾病靶点672个，姜黄素作用靶点107个，筛选出20个关键靶点。GO和KEGG分析表明，姜黄素可能通过缺氧诱导因子(HIF)-1和甲状旁腺激素(PTH)信号通路发挥治疗作用。分子对接分析表明，姜黄素与多种靶点具有良好的结合潜力。结论:姜黄素治疗牙周炎的潜在关键靶点和分子机制为姜黄素的新药开发和临床应用提供了理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

华西口腔医学杂志 Medicine-Medicine (all)

CiteScore

0.80

自引率

0.00%

发文量

6397

期刊介绍： West China Journal of Stomatology (WCJS, pISSN 1000-1182, eISSN 2618-0456, CN 51-1169/R), published bimonthly, is a peer-reviewed Open Access journal, hosted by Sichuan university and Ministry of Education of the People's Republic of China. WCJS was established in 1983 and indexed in Medline/Pubmed, SCOPUS, EBSCO, Chemical Abstract(CA), CNKI, WANFANG Data, etc.