Can cannabidiol have an analgesic effect?

IF 2.1 4区医学 Q3 PHARMACOLOGY & PHARMACY

Fundamental & Clinical Pharmacology Pub Date : 2023-08-16 DOI:10.1111/fcp.12947

Bartłomiej Kulesza, Marek Mazurek, Jacek Kurzepa

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Abstract

Background

Cannabis, more commonly known as marijuana or hemp, has been used for centuries to treat various conditions. Cannabis contains two main components cannabidiol (CBD) and tetrahydrocannabinol (THC). CBD, unlike THC, is devoid of psychoactive effects and is well tolerated by the human body but has no direct effect on the receptors of the endocannabid system, despite the lack of action on the receptors of the endocannabid system.

Objectives and methods

We have prepared a literature review based on the latest available literature regarding the analgesic effects of CBD. CBD has a wide range of effects on the human body. In this study, we will present the potential mechanisms responsible for the analgesic effect of CBD. To the best of our knowledge, this is the first review to explore the analgesic mechanisms of CBD.

Results and conclusion

The analgesic effect of CBD is complex and still being researched. CBD models the perception of pain by acting on G protein-coupled receptors. Another group of receptors that CBD acts on are serotonergic receptors. The effect of CBD on an enzyme of potential importance in the production of inflammatory factors such as cyclooxygenases and lipoxygenases has also been confirmed. The presented potential mechanisms of CBD's analgesic effect are currently being extensively studied.

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大麻二酚有镇痛作用吗？

背景：几个世纪以来，大麻（通常称为大麻或大麻）一直被用于治疗各种疾病。大麻含有两种主要成分大麻二酚（CBD）和四氢大麻酚（THC）。CBD 与四氢大麻酚不同，没有精神活性作用，人体耐受性好，但对内源性大麻酚系统的受体没有直接作用：我们根据现有关于 CBD 镇痛作用的最新文献编写了一份文献综述。CBD 对人体有广泛的影响。在本研究中，我们将介绍 CBD 镇痛作用的潜在机制。据我们所知，这是第一篇探讨 CBD 镇痛机制的综述：CBD 的镇痛作用非常复杂，目前仍在研究之中。CBD 通过作用于 G 蛋白偶联受体来模拟对疼痛的感知。CBD 作用的另一组受体是血清素能受体。此外，还证实了 CBD 对产生环氧化酶和脂氧合酶等炎症因子的一种潜在重要酶的影响。目前正在对 CBD 镇痛作用的潜在机制进行广泛研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fundamental & Clinical Pharmacology 医学-药学

CiteScore

5.30

自引率

6.90%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Fundamental & Clinical Pharmacology publishes reports describing important and novel developments in fundamental as well as clinical research relevant to drug therapy. Original articles, short communications and reviews are published on all aspects of experimental and clinical pharmacology including: Antimicrobial, Antiviral Agents Autonomic Pharmacology Cardiovascular Pharmacology Cellular Pharmacology Clinical Trials Endocrinopharmacology Gene Therapy Inflammation, Immunopharmacology Lipids, Atherosclerosis Liver and G-I Tract Pharmacology Metabolism, Pharmacokinetics Neuropharmacology Neuropsychopharmacology Oncopharmacology Pediatric Pharmacology Development Pharmacoeconomics Pharmacoepidemiology Pharmacogenetics, Pharmacogenomics Pharmacovigilance Pulmonary Pharmacology Receptors, Signal Transduction Renal Pharmacology Thrombosis and Hemostasis Toxicopharmacology Clinical research, including clinical studies and clinical trials, may cover disciplines such as pharmacokinetics, pharmacodynamics, pharmacovigilance, pharmacoepidemiology, pharmacogenomics and pharmacoeconomics. Basic research articles from fields such as physiology and molecular biology which contribute to an understanding of drug therapy are also welcomed.