Pyrimidinergic receptor P2Y6 expression is elevated in lung adenocarcinoma and is associated with poor prognosis.

IF 2.2 4区医学 Q3 ONCOLOGY

Cancer Biomarkers Pub Date : 2023-01-01 DOI:10.3233/CBM-230137

Xiuli Wang, Baoshan Zhao, Dan Ren, Xiaolei Hu, Juanjuan Qiao, Dongmei Zhang, Yanzhi Zhang, Yu Pan, Yuhua Fan, Lili Liu, Xiaoxue Wang, Huanhuan Ma, Xueling Jia, Sihang Song, Chong Zhao, Jingbo Liu, Lin Wang

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引用次数: 0

Abstract

Backgroud: Previous in vitro studies have indicated that pyrimidinergic receptor P2Y6 (P2RY6, P2Y6 receptor) may function as a cancer-promoting factor in lung adenocarcinoma (LUAD). However, the prognostic significance of P2RY6 expression in LUAD has not been investigated.

Objective: This study aimed to assess the impact of P2RY6 expression on the survival of patients with LUAD.

Methods: First, we assessed P2RY6 mRNA and protein expression in LUAD and non-cancerous lung tissues using the online bioinformatics analysis tool GEPIA, fresh LUAD tissues, and LUAD tissue microarrays (TMAs). Second, we investigated the correlation between P2RY6 expression and clinicopathological parameters of LUAD patients based on data from The Cancer Genome Atlas (TCGA) database and TMAs. Finally, we analyzed the prognostic significance of P2RY6 expression in LUAD using the online survival analysis tool Kaplan-Meier Plotter and data from TMAs.

Results: We demonstrated that P2RY6 mRNA and protein expression levels in LUAD tissues were significantly higher than those in non-cancerous lung tissues. The expression of P2RY6 in LUAD was positively correlated with poor differentiation, more lymph node metastasis, and more advanced clinical stage. Higher P2RY6 expression level was correlated with shorter survival of the LUAD patients. Univariate and multivariate Cox regression analyses indicated that higher P2RY6 tumor expression was an independent unfavorable prognostic factor for LUAD patients.

Conclusions: P2RY6 expression was elevated in LUAD and correlated with poor prognosis.

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嘧啶能受体P2Y6在肺腺癌中表达升高，与预后不良有关。

背景：先前的体外研究表明，嘧啶能受体P2Y6（P2RY6，P2Y6受体）可能在肺腺癌（LUAD）中起到促癌因子的作用。然而，P2RY6在LUAD中的表达对预后的意义尚未得到研究。目的：本研究旨在评估P2RY6表达对LUAD患者生存的影响。方法：首先，我们使用在线生物信息学分析工具GEPIA、新鲜LUAD组织和LUAD组织微阵列（TMAs）评估P2RY6mRNA和蛋白在LUAD和非癌性肺组织中的表达。其次，我们基于癌症基因组图谱（TCGA）数据库和TMAs的数据，研究了LUAD患者P2RY6表达与临床病理参数之间的相关性。最后，我们使用在线生存分析工具Kaplan-Meier Plotter和TMAs数据分析了P2RY6在LUAD中的表达对预后的意义。结果：我们发现LUAD组织中P2RY6mRNA和蛋白的表达水平显著高于非癌性肺组织。P2RY6在LUAD中的表达与分化差、淋巴结转移多和临床分期晚期呈正相关。P2RY6表达水平越高，LUAD患者的生存期越短。单变量和多变量Cox回归分析表明，较高的P2RY6肿瘤表达是LUAD患者的独立不利预后因素。结论：P2RY6在LUAD中表达升高，与预后不良有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Biomarkers ONCOLOGY-

CiteScore

5.20

自引率

3.20%

发文量

195

审稿时长

3 months

期刊介绍： Concentrating on molecular biomarkers in cancer research, Cancer Biomarkers publishes original research findings (and reviews solicited by the editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion. The disease markers may include, but are not limited to, genomic, epigenomic, proteomics, cellular and morphologic, and genetic factors predisposing to the disease or indicating the occurrence of the disease. Manuscripts on these factors or biomarkers, either in altered forms, abnormal concentrations or with abnormal tissue distribution leading to disease causation will be accepted.