Cancer Chemistry

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Cancer Chemistry - 最新文献

Abstract LB003: Fragment based discovery of MRTX9768, a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors

Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-LB003 Christopher R. Smith, Kulyk Svitlana, J. Lawson, Lars D. Engstrom, Ruth Aranda, David M Briere, Robin J. Gunn, K. Moya, L. Rahbaek, Laurie Waters, A. Ivetac, J. Christensen, P. Olson, M. Marx

Abstract 298: Dissection of drug-protein interactions by HR-LiP-MS in target validation and lead optimization

Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-298 N. Beaton, J. Adhikari, Yuehan Feng, R. Bruderer, R. Tomlinson, I. Cornella-Taracido, L. Reiter

Abstract 323: Quantitative proteomic profiling of novel anti-cancer small molecule inhibitors of Sec61: Mechanistic investigation and biomarker discovery

Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-323 Yu Qian, Jennifer A. Whang, J. Anderl, H. Johnson, C. Kirk, E. Lowe, D. McMinn, Beatriz Millare, T. Muchamuel, Jinhai Wang

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