ImmunoHorizons

Safety, pharmacokinetics, and pharmacodynamics of MK-6194, an IL-2 mutein designed to selectively activate regulatory T cells: single ascending dose and multiple ascending dose trial data.

Pub Date : 2025-03-26 DOI: 10.1093/immhor/vlaf005 Johannes F Scheid, Kiki Cunningham-Bussel, Nancy Kim, Shiuli Agarwal, Garrett Nieddu, Josee Cote, Lieselotte Lemoine, Tatjana Decaesteker, Luis Mendez, Erina Paul, Latisha Love-Gregory, Alejandra Virginia Contreras, Xuemei Zhao, Lucia Franco-Dilone, Ling Pang, Gretchen A Baltus, Maribel Beaumont, Ketal Shah, Nathan Higginson-Scott, Katalin Kis-Toth, Kevin L Otipoby, Joanne L Viney, Eric Sicard, Sylvie Rottey, John S Sundy, Kristien Van Dyck, Tine Laethem, Patrick Larson, Santosh Sutradhar, Richard Wnek, Tjerk Bueters, Eseng Lai, S Aubrey Stoch, Marian Iwamoto, Jonathan A Robbins

In vitro and in vivo neutralization of Dengue virus by a single domain antibody.

Pub Date : 2025-03-26 DOI: 10.1093/immhor/vlaf012 Surbhi Dahiya, Sudhakar Singh, Gaurav Kumar Bhati, Sharvan Sehrawat

Microbiome-mediated modulation of immune memory to P. yoelii affects the resistance to secondary cerebral malaria challenge.

Pub Date : 2025-03-26 DOI: 10.1093/immhor/vlaf009 Elizabeth M Fusco, Layne Bower, Rafael Polidoro, Allen M Minns, Scott E Lindner, Nathan W Schmidt