Expert opinion on drug metabolism & toxicology

Evaluation of the role of comedication properties in the severity of drug-induced liver injury using machine learning techniques.

Pub Date : 2025-07-06 DOI: 10.1080/17425255.2025.2525470 Irene Victoria Bermúdez-Pérez, Ismael Alvarez-Alvarez, Inmaculada Medina-Cáliz, Mercedes Robles-Diaz, Hao Niu, Minjun Chen, Raúl J Andrade, Mª Isabel Lucena, Camilla Stephens, Andrés Gonzalez-Jimenez

Lessons learned from aldehyde dehydrogenases as non-P450 aldehyde-oxidizing enzymes: implications for the 'exposome' and human health.

Pub Date : 2025-07-02 DOI: 10.1080/17425255.2025.2524872 Athina Lisgara, David C Thompson, Daniel W Nebert, Vasilis Vasiliou

Mass balance and metabolite profiles in humans of tegoprazan, a novel potassium-competitive acid blocker, using ¹⁴C-radiolabelled techniques.

Pub Date : 2025-07-01 DOI: 10.1080/17425255.2025.2505637 Yicong Bian, Jinjie Yuan, Sheng Ma, Jiang Nan, Zheming Gu, Hao Feng, Zhenwen Yu, Zhenteng Liu, Fang Xie, Yinghui Wang, Chengxin Liu, Hua Zhang, Liyan Miao