Molecular neurodegeneration advances

Proteomic analysis of human chronic traumatic encephalopathy brain implicates proteasome and ribosome dysfunction in disease severity.

Pub Date : 2026-01-01 DOI: 10.1186/s44477-026-00045-w Helen E Pennington, Dillon Shapiro, Jenny Empawi, Nurgul Aytan, Victor E Alvarez, Jessie Mez, Michael L Alosco, Xiaoling Zhang, Ann C McKee, Thor D Stein, Jonathan D Cherry, Adam Labadorf

CSF proteomic quantitative trait loci mapping reveals genetic insights into Alzheimer's disease.

Pub Date : 2026-01-01 DOI: 10.1186/s44477-026-00048-7 Lianne M Reus, Chenyang Jiang, Natalia Vilor-Tejedor, Toni Boltz, Arya Yigit, Johan Gobom, Stephanie J B Vos, Kaj Blennow, Henrik Zetterberg, Pablo Martinez-Lage, Mikel Tainta, Julius Popp, Magda Tsolaki, Rik Vandenberghe, Lutz Frölich, Yvonne Freund-Levi, Valerija Dobricic, Anouk den Braber, Argonde C van Harten, Roel A Ophoff, Henne Holstege, Wiesje M van der Flier, Sven J van der Lee, Charlotte E Teunissen, Lars Bertram, Pieter Jelle Visser, Betty M Tijms

C3 lowering in adult APP KI mice rescues synapses and spares cognitive decline.

Pub Date : 2026-01-01 DOI: 10.1186/s44477-025-00009-6 Brijendra Singh, Andre F Batista, Emma T Spooner, Brianna R Colletti, Takaomi C Saido, Michael C Carroll, Cynthia A Lemere