ALTEX

Evaluation of a high-throughput in-vitro-to-in-vivo extrapolation (IVIVE) workflow for the prioritization of potential developmental toxicity of chemicals.

Pub Date : 2025-05-28 DOI: 10.14573/altex.2406281 Matthew W Linakis, Rebecca A Clewell, Jerry Campbell, P Robinan Gentry, Harvey J Clewell

From cellular perturbation to probabilistic risk assessments.

Pub Date : 2025-05-26 DOI: 10.14573/altex.2501291 Alexandra Maertens, Breanne Kincaid, Eric Bridgeford, Celine Brochot, Arthur de Carvalho E Silva, Jean-Lou C M Dorne, Liesbet Geris, Trine Husøy, Nicole Kleinstreuer, Luiz C M Ladeira, Alistair Middleton, Joe Reynolds, Blanca Rodriguez, Erwin L Roggen, Giulia Russo, Kris Thayer, Thomas Hartung

Determination of U-SENS™ borderline range thresholds to address uncertainty for skin sensitization assessment in a regulatory context.

Pub Date : 2025-05-23 DOI: 10.14573/altex.2411282 Laurent Nardelli, Fleur Tourneix, Leopold Carron, Erwin van Vliet, Nathalie Alépée