NPJ drug discovery

Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining.

Pub Date : 2025-01-01 DOI: 10.1038/s44386-025-00006-5 Karla P Godinez-Macias, Daisy Chen, J Lincoln Wallis, Miles G Siegel, Anna Adam, Selina Bopp, Krypton Carolino, Lauren B Coulson, Greg Durst, Vandana Thathy, Lisl Esherick, Madeline A Farringer, Erika L Flannery, Barbara Forte, Tiqing Liu, Luma Godoy Magalhaes, Anil K Gupta, Eva S Istvan, Tiantian Jiang, Krittikorn Kumpornsin, Karen Lobb, Kyle J McLean, Igor M R Moura, John Okombo, N Connor Payne, Andrew Plater, Srinivasa P S Rao, Jair L Siqueira-Neto, Bente A Somsen, Robert L Summers, Rumin Zhang, Michael K Gilson, Francisco-Javier Gamo, Brice Campo, Beatriz Baragaña, James Duffy, Ian H Gilbert, Amanda K Lukens, Koen J Dechering, Jacquin C Niles, Case W McNamara, Xiu Cheng, Lyn-Marie Birkholtz, Alfred W Bronkhorst, David A Fidock, Dyann F Wirth, Daniel E Goldberg, Marcus C S Lee, Elizabeth A Winzeler

Structural and mechanistic study of a novel inhibitor analogue of M. tuberculosis cytochrome bc₁:aa₃.

Pub Date : 2025-01-01 DOI: 10.1038/s44386-025-00008-3 Amit K Verma, Robbert Q Kim, Dirk A Lamprecht, Clara Aguilar-Pérez, Sarah Wong, Nicolas Veziris, Alexandra Aubry, José M Bartolomé-Nebreda, Rodrigo J Carbajo, Jennefer Wetzel, Meindert H Lamers

Intracellular GPCR modulators enable precision pharmacology.

Pub Date : 2025-01-01 DOI: 10.1038/s44386-025-00011-8 Brian E Krumm, Bryan L Roth