The Journal of Clinical Investigation

Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis-induced cytokine transcriptional responses.

Pub Date : 2025-05-22 DOI: 10.1172/jci179822 Joshua J Ivie,Kimberly A Dill-McFarland,Jason D Simmons,Glenna J Peterson,Penelope H Benchek,Harriet Mayanja-Kizza,Lily E Veith,Moeko Agata,Dang Tm Ha,Ho Dt Nghia,W Henry Boom,Catherine M Stein,Chiea C Khor,Guy E Thwaites,Hoang T Hai,Nguyen Tt Thuong,Xuling Chang,Sarah J Dunstan,Thomas R Hawn

Integrin-mediated mTOR signaling drives TGF-β overactivity and myxomatous mitral valve degeneration in hypomorphic fibrillin-1 mice.

Pub Date : 2025-05-20 DOI: 10.1172/jci183558 Fu Gao,Qixin Chen,Makoto Mori,Sufang Li,Giovanni Ferrari,Markus Krane,Rong Fan,George Tellides,Yang Liu,Arnar Geirsson

Trapα deficiency impairs the early events of insulin biosynthesis and glucose homeostasis.

Pub Date : 2025-05-20 DOI: 10.1172/jci179845 Xin Li,Jingxin Hu,Yumeng Huang,Hai Zhang,Ning Xu,Yang Liu,Xuan Liu,Yuanyuan Ye,Xinxin Zhang,Xiaoxi Xu,Yuxin Fan,Ziyue Zhang,Weiping J Zhang,Shusen Wang,Wenli Feng,Peter Arvan,Ming Liu