The Journal of Clinical Investigation

Antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and suppresses pancreatic tumorigenesis.

Pub Date : 2025-09-16 DOI: 10.1172/jci184172 Thomas Mandel Clausen,Ryan J Weiss,Jacob R Tremblay,Benjamin P Kellman,Joanna Coker,Leo A Dworkin,Jessica P Rodriguez,Ivy M Chang,Timothy Chen,Vikram Padala,Richard Karlsson,Hyemin Song,Kristina L Peck,Satoshi Ogawa,Daniel R Sandoval,Hiren J Joshi,Gaowei Wang,L Paige Ferguson,Nikita Bhalerao,Allison Moores,Tannishtha Reya,Maike Sander,Thomas C Caffrey,Jean L Grem,Alexandra Aicher,Christopher Heeschen,Dzung Le,Nathan E Lewis,Michael A Hollingsworth,Paul M Grandgenett,Susan L Bellis,Rebecca L Miller,Mark M Fuster,David W Dawson,Dannielle D Engle,Jeffrey D Esko

Targeting peroxiredoxin 2 prevents hepatocarcinogenesis in metabolic liver disease.

Pub Date : 2025-09-11 DOI: 10.1172/jci169395 Emilie Crouchet,Eugénie Schaeffer,Marine A Oudot,Julien Moehlin,Cloé Gadenne,Frank Jühling,Hussein El Saghire,Naoto Fujiwara,Shijia Zhu,Fahmida Akter Rasha,Sarah C Durand,Anouk Charlot,Clara Ponsolles,Romain Martin,Nicolas Brignon,Fabio Del Zompo,Laura Meiss Heydmann,Marie Parnot,Nourdine Hamdane,Danijela Heide,Jenny Hetzer,Mathias Heikenwälder,Emanuele Felli,Patrick Pessaux,Nathalie Pochet,Joffrey Zoll,Brian Cunniff,Yujin Hoshida,Laurent Mailly,Thomas F Baumert,Catherine Schuster

Recessive TMEM167A variants cause neonatal diabetes, microcephaly and epilepsy syndrome.

Pub Date : 2025-09-09 DOI: 10.1172/jci195756 Enrico Virgilio,Sylvia Tielens,Georgia Bonfield,Fang-Shin Nian,Toshiaki Sawatani,Chiara Vinci,Molly Govier,Hossam Montaser,Romane Lartigue,Anoop Arunagiri,Alexandrine Liboz,Flavia Natividade da Silva,Maria Lytrivi,Theodora Papadopoulou,Matthew N Wakeling,James Russ-Silsby,Pamela Bowman,Matthew B Johnson,Thomas W Laver,Anthony Piron,Xiaoyan Yi,Federica Fantuzzi,Sirine Hendrickx,Mariana Igoillo-Esteve,Bruno J Santacreu,Jananie Suntharesan,Radha Ghildiyal,Darshan G Hegde,Nikhil Avnish Shah,Sezer Acar,Beyhan Özkaya Dönmez,Behzat Özkan,Fauzia Mohsin,Iman M Talaat,Mohamed Tarek Abbas,Omar Saied Abbas,Hamed Ali Alghamdi,Nurgun Kandemir,Sarah E Flanagan,Raphael Scharfmann,Peter Arvan,Matthieu Raoux,Laurent Nguyen,Andrew T Hattersley,Miriam Cnop,Elisa De Franco