The Journal of Clinical Investigation

Ketogenesis mitigates metabolic dysfunction-associated steatotic liver disease through mechanisms that extend beyond fat oxidation.

Pub Date : 2025-04-24 DOI: 10.1172/jci191021 Eric D Queathem,David B Stagg,Alisa B Nelson,Alec B Chaves,Scott B Crown,Kyle Fulghum,D Andre d'Avignon,Justin R Ryder,Patrick J Bolan,Abdirahman Hayir,Jacob R Gillingham,Shannon Jannatpour,Ferrol I Rome,Ashley S Williams,Deborah M Muoio,Sayeed Ikramuddin,Curtis C Hughey,Patrycja Puchalska,Peter A Crawford

Colistin exerts potent activity against mcr+ Enterobacteriaceae via synergistic interactions with the host defense.

Pub Date : 2025-04-22 DOI: 10.1172/jci170690 Monika Kumaraswamy,Angelica Riestra,Anabel Flores,Samira Dahesh,Fatemeh Askarian,Satoshi Uchiyama,Jonathan Monk,Sean Jung,Gunnar Bondsäter,Victoria Nilsson,Melanie Chang,Jürgen B Bulitta,Yinzhi Lang,Armin Kousha,Elisabet Bjånes,Natalie Chavarria,Ty'Tianna Clark,Hideya Seo,George Sakoulas,Victor Nizet

Antimicrobial Peptide Developed with Machine Learning Sequence Optimization Targets Drug Resistant Staphylococcus aureus in Mice.

Pub Date : 2025-04-22 DOI: 10.1172/jci185430 Biswajit Mishra,Anindya Basu,Fadi Shehadeh,LewisOscar Felix,Sai Sundeep Kollala,Yashpal Singh Chhonker,Mandar T Naik,Charilaos Dellis,Liyang Zhang,Narchonai Ganesan,Daryl J Murry,Jianhua Gu,Michael B Sherman,Frederick M Ausubel,Paul P Sotiriadis,Eleftherios Mylonakis