The Journal of Clinical Investigation

Mitochondrial metabolic dysfunction in airway epithelial cells promotes goblet cell metaplasia and more severe asthma

Pub Date : 2026-10-06 DOI: 10.1172/jci200067 Xiuxia Zhou,Krithika S. Rao,Sruti Shiva,Catharina van Heusden,Qi Wei,Nobuhiko Fukuda,Mayoko Tsuji,Angelina Kendi,Laura R. Bradley,Jinming Zhao,John B. Trudeau,Anuradha Ray,Richard C. Boucher,Sally E. Wenzel

Pharmacologic HIF-2α inhibition preserves T cell effector function in clear cell renal cell carcinoma

Pub Date : 2026-10-06 DOI: 10.1172/jci204613 Katrine N. Madsen,Soki Kashima,Hanna Soulati,Lena Wirth,Katsuhiro Ito,Zachary A. Yochum,Vivien Moritz,Julia Walker,Marc Machaalani,Fady Ghali,Patrick Kenney,Adebowale Adeniran,Michael Hurwitz,Toni K. Choueiri,David A. Braun

Impact of sexual debut on urethral immunology and microbiome in adolescent males from Rakai, Uganda

Pub Date : 2026-10-06 DOI: 10.1172/jci208629 Rameen Jamil,Sanja Huibner,Ping Yang,James Nnamutete,Jodie L. White,Lori Sokoll,James Pollock,Margaret Nakalanzi,Simon Peter Bukenya,Stephen D. Kiboneka,Mathias Agaba,Mary J. Nalubowa,Aggrey Anok,Godfrey Kigozi,Ronald M. Galiwango,Bryan Coburn,Cindy M. Liu,Jessica L. Prodger,Aaron A.R. Tobian,Rupert Kaul