The Journal of Clinical Investigation

Dual targeting CDK4/6 and CDK7 augments tumor response and anti-tumor immunity in breast cancer models.

Pub Date : 2025-08-12 DOI: 10.1172/jci188839 Sungsoo Kim,Eugene Son,Ha-Ram Park,Minah Kim,Hee Won Yang

Platelet-specific SLFN14 deletion causes macrothrombocytopenia and platelet dysfunction through dysregulated megakaryocyte and platelet gene expression.

Pub Date : 2025-08-12 DOI: 10.1172/jci189100 Rachel J Stapley,Xenia Sawkulycz,Gabriel Hm Da Mota Araujo,Maximilian Englert,Lourdes Garcia-Quintanilla,Sophie Rm Smith,Amna Ahmed,Elizabeth J Haining,Nayandeep Kaur,Andrea Bacon,Andrey V Pisarev,Natalie S Poulter,Dean Pj Kavanagh,Steven G Thomas,Samantha J Montague,Julie Rayes,Zoltan Nagy,Neil V Morgan

TET3 is a common epigenetic immunomodulator of pathogenic macrophages.

Pub Date : 2025-08-12 DOI: 10.1172/jci194879 Beibei Liu,Yangyang Dai,Zixin Wang,Jiahui Song,Yushu Du,Haining Lv,Stefania Bellone,Yang-Hartwich Yang,Andrew Kennedy,Songying Zhang,Muthukumaran Venkatachalapathy,Yulia V Surovtseva,Penghua Wang,Gordon G Carmichael,Hugh S Taylor,Xuchen Zhang,Da Li,Yingqun Huang