The Journal of Clinical Investigation

Tagless LysoIP for immunoaffinity enrichment of native lysosomes from clinical samples.

Pub Date : 2024-12-26 DOI: 10.1172/jci183592 Daniel Saarela,Pawel Lis,Sara Gomes,Raja S Nirujogi,Wentao Dong,Eshaan S Rawat,Sophie Glendinning,Karolina Zeneviciute,Enrico Bagnoli,Rotimi Fasimoye,Cindy Lin,Kwamina Nyame,Fanni A Boros,Friederike Zunke,Frederic Lamoliatte,Sadik Elshani,Matthew Jaconelli,Judith Jm Jans,Margriet A Huisman,Christian Posern,Lena M Westermann,Angela Schulz,Peter M van Hasselt,Dario R Alessi,Monther Abu-Remaileh,Esther M Sammler

Non-classical action of Ku70 promotes Treg suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma.

Pub Date : 2024-10-24 DOI: 10.1172/jci178079 Qianru Huang,Na Tian,Jianfeng Zhang,Shiyang Song,Hao Cheng,Xinnan Liu,Wenle Zhang,Youqiong Ye,Yanhua Du,Xueyu Dai,Rui Liang,Dan Li,Sheng-Ming Dai,Chuan Wang,Zhi Chen,Qianjun Zhou,Bin Li

Frameshift mutation spectra overlap between constitutional mismatch repair deficiency tumors and Lynch syndrome tumors.

Pub Date : 2024-10-22 DOI: 10.1172/jci185999 Yurong Song,Ryan N Baugher,Todd B Young,Brandon Somerville,Yuriko Mori,Ligia A Pinto,Kim E Nichols,Robert H Shoemaker