The Journal of Clinical Investigation

TSC/mTORC1 mediates mTORC2/AKT1 signaling in c-MYC-induced murine hepatocarcinogenesis via centromere protein M.

Pub Date : 2024-09-26 DOI: 10.1172/jci174415 Yi Zhou,Shu Zhang,Guoteng Qiu,Xue Wang,Andrew Yonemura,Hongwei Xu,Guofei Cui,Shanshan Deng,Joanne Chun,Nianyong Chen,Meng Xu,Xinhua Song,Jingwen Wang,Zijing Xu,Youping Deng,Matthias Evert,Diego F Calvisi,Shumei Lin,Haichuan Wang,Xin Chen

YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production.

Pub Date : 2024-09-26 DOI: 10.1172/jci181612 Chuangyu Wen,Liangliang Wang,András Piffkó,Dapeng Chen,Xianbin Yu,Katarzyna Zawieracz,Jason Bugno,Kaiting Yang,Emile Z Naccasha,Fei Ji,Jiaai Wang,Xiaona Huang,Stephen Y Luo,Lei Tan,Bin Shen,Cheng Luo,Megan E McNerney,Steven J Chmura,Ainhoa Arina,Sean P Pitroda,Chuan He,Hua Liang,Ralph R Weichselbaum

Stimulation of an entorhinal-hippocampal extinction circuit facilitates fear extinction in a post-traumatic stress disorder model.

Pub Date : 2024-09-24 DOI: 10.1172/jci181095 Ze-Jie Lin,Xue Gu,Wan-Kun Gong,Mo Wang,Yan-Jiao Wu,Qi Wang,Xin-Rong Wu,Xin-Yu Zhao,Michael X Zhu,Lu-Yang Wang,Quanying Liu,Ti-Fei Yuan,Wei-Guang Li,Tian-Le Xu