The Journal of Clinical Investigation

Monocytes and interstitial macrophages contribute to hypoxic pulmonary hypertension.

Pub Date : 2025-01-30 DOI: 10.1172/jci176865 Rahul Kumar,Kevin Nolan,Biruk Kassa,Neha Chanana,Tsering Palmo,Kavita Sharma,Kanika Singh,Claudia Mickael,Dara Fonseca Balladares,Julia Nilsson,Amit Prabhakar,Aastha Mishra,Michael H Lee,Linda Sanders,Sushil Kumar,Ari B Molofsky,Kurt R Stenmark,Dean Sheppard,Rubin M Tuder,Mohit D Gupta,Tashi Thinlas,Qadar Pasha,Brian B Graham

Passive transfer of patient-derived anti-nephrin autoantibodies causes a podocytopathy with minimal change lesions.

Pub Date : 2025-01-16 DOI: 10.1172/jci186769 Felicitas E Hengel,Silke Dehde,Oliver Kretz,Jonas Engesser,Tom Zimmermann,Tobias B Huber,Nicola M Tomas

Tagless LysoIP for immunoaffinity enrichment of native lysosomes from clinical samples.

Pub Date : 2024-12-26 DOI: 10.1172/jci183592 Daniel Saarela,Pawel Lis,Sara Gomes,Raja S Nirujogi,Wentao Dong,Eshaan S Rawat,Sophie Glendinning,Karolina Zeneviciute,Enrico Bagnoli,Rotimi Fasimoye,Cindy Lin,Kwamina Nyame,Fanni A Boros,Friederike Zunke,Frederic Lamoliatte,Sadik Elshani,Matthew Jaconelli,Judith Jm Jans,Margriet A Huisman,Christian Posern,Lena M Westermann,Angela Schulz,Peter M van Hasselt,Dario R Alessi,Monther Abu-Remaileh,Esther M Sammler