Bioorganic & Medicinal Chemistry

Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design

Pub Date : 2024-02-01 DOI: 10.1016/j.bmc.2024.117638 Chunjian Liu, Wei Wang, Jianxin Feng, Brett Beno, Thiruvenkadam Raja, Jacob J. Swidorski, Raju K. V. L. P. Manepalli, Muthalagu Vetrichelvan, Prasada Rao Jalagam, Satheesh K. Nair, Anuradha Gupta, Manoranjan Panda, Kaushik Ghosh, Jinal Kaushikkumar Shukla, Harinath Sale, Devang Shah, Shashyendra Singh Gautam, Dipal Patel, A. Mathur, B. Ellsworth, Dong Cheng, Alicia Regueiro-Ren

3-Amino-5,6,7,8-tetrahydrothieno[2,3–b]quinoline-2-carbonitrile: a fluorescent molecule that induces differentiation in PC12 cells

Pub Date : 2024-02-01 DOI: 10.1016/j.bmc.2024.117637 Kazuya Asao, Kento Sonoda, Shin-ichi Kawaguchi, Yoshinori Kawazoe