The EMBO Journal

ALS-associated RNA-binding proteins promote UNC13A transcription through REST downregulation.

Pub Date : 2025-07-24 DOI: 10.1038/s44318-025-00506-0 Yasuaki Watanabe,Naoki Suzuki,Tadashi Nakagawa,Masaki Hosogane,Tetsuya Akiyama,Naotoshi Kageyama,Yukino Funayama,Hitoshi Warita,Satoru Morimoto,Hideyuki Okano,Masashi Aoki,Keiko Nakayama

Deletion of EP3 prostaglandin receptor in murine macrophages aggravates diet-induced obesity by suppressing SPARC.

Pub Date : 2025-07-23 DOI: 10.1038/s44318-025-00508-y Wenlong Shang,Yinxiu Li,Lu Wang,Jiao Liu,Huiwen Ren,Qian Liu,Shumin Guo,Yuhong Wang,Yubo Ma,Tianyi You,Yujun Shen,Yu Zhou,Danyang Tian,Ying Yu

Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fate.

Pub Date : 2025-07-21 DOI: 10.1038/s44318-025-00504-2 Michael Namestnikov,Osnat Cohen-Zontag,Dorit Omer,Yehudit Gnatek,Sanja Goldberg,Thomas Vincent,Swati Singh,Yair Shiber,Tal Rafaeli Yehudai,Hadas Volkov,Dani Folkman Genet,Achia Urbach,Sylvie Polak-Charcon,Igor Grinberg,Naomi Pode-Shakked,Boaz Weisz,Zvi Vaknin,Benjamin S Freedman,Benjamin Dekel