The EMBO Journal

Tau uptake by human neurons depends on receptor LRP1 and kinase LRRK2.

Pub Date : 2025-08-11 DOI: 10.1038/s44318-025-00514-0 Lewis D Evans,Alessio Strano,Eleanor Tuck,Ashley Campbell,James Smith,Christy Hung,Tiana S Behr,Bernardino Ghetti,Benjamin Ryskeldi-Falcon,Emre Karakoc,Francesco Iorio,Alastair Reith,Andrew R Bassett,Frederick J Livesey

Hepatic ASPG-mediated lysophosphatidylinositol catabolism impairs insulin signal transduction.

Pub Date : 2025-08-04 DOI: 10.1038/s44318-025-00525-x Feiyan Li,Hua-Sheng Huang,Qingwen Zhao,Wei Zhang,Ting Shi,Wenjing Lv,Qi Zhu,Haojie Liu,Yingjiang Xu,Haiyan Huang,Qi-Qun Tang,Yue Gao,Tao Peng,Dongning Pan

NRAC controls CD36-mediated fatty acid uptake in adipocytes and lipid clearance in vivo.

Pub Date : 2025-08-01 DOI: 10.1038/s44318-025-00520-2 Inderjeet Singh,Yasuhiro Onogi,Filipe Menezes,Dina Khasanova,Lingru Kang,Chenxi Wang,Julio Ruiz-Trave,Sapna Sharma,Ahmed Khalil,Valentin K Reichenbach,Yingzi Shi,Andrew Flatley,Xiaocheng Yan,Andreas Israel,Nathalia R V Dragano,Juan Antonio Aguilar-Pimentel,Anne Hoffmann,Adhideb Ghosh,Falko Noé,Christian Wolfrum,Sebastian Cucuruz,Ann-Christine König,Ingo Burtscher,Stefanie M Hauck,Heiko Lickert,Susanna M Hofmann,Regina Feederle,Sonja C Schriever,Rene Hernandez-Bautista,Gencer Sancar,Alberto Cebrian-Serrano,Igor Tetko,Helmut Fuchs,Valérie Gailus-Durner,Matthias Blüher,Martin Hrabě de Angelis,Siegfried Ussar