Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase

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DOI:10.1021/acs.jmedchem.4c02897
作者：Gebhard Thoma, Wolfgang Miltz, Rudolf Waelchli, David Orain, Carsten Spanka, Odile Decoret, Romain M. Wolf, Brian Hurley, Atwood K. Cheung, David A. Sandham, Ayako Honda, Ritesh Tichkule, Xin Chen, Ta
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American Chemical Society (ACS)

Abstract：Leukotriene C4 synthase (LTC4S) is a glutathione S-transferase that mediates the biosynthesis of cysteinyl leukotriene C4 (LTC4). Cysteinyl leukotrienes (CysLTs) are lipid mediators that dri

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