Early Process Development of a Heterobifunctional Protein Degrader

已完结 10 由 leek 发布于 2026/4/20 11:04:01

DOI:10.1021/acs.oprd.5c00458
作者：Michael C. Haibach*,?, ,?Russell Klix,?, ,?Sarma Pullela,?, ,?Moussa Boukerche,?, ,?Dane Holte,?, ,?Jingyu Guo,?, ,?Jiacheng Yao,?, ,?Cheng Shen,?, ,?Eric G. Moschetta,?, ,?Jason Wang,?, ,?Shuang Chen
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：We present the process development of 1, a heterobifunctional Bruton’s Tyrosine Kinase (BTK) degrader. Optimization and reorganization of the discovery synthesis resulted in a scalable proce

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