Discovery of a potent thienodiazepine derivative as a novel BRD4 degrader

已完结 10 由啦发布于 2026/4/19 23:51:09

DOI:10.1016/j.bmc.2026.118583
作者：Mayu Shigekuni , Yasuki Niwa , Kiyomi Ohba, Maiko Hamada, Hideto Maruyama, Shiki Miyazaki, Daisuke Iijima, Shinsuke Ooike, Ryo Fujita, Yasufumi Fukano,&nbs
文献类型：期刊论文
补充材料：只需要正文

Elsevier

Abstract：We discovered bromodomain-containing protein 4 (BRD4) degraders as novel antitumor therapeutics leveraging our internal knowledge on Y-803 (birabresib, OTX015/MK-8628), which was discovered

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