Extracellular CD44 lactylation impairs CD8+ T cell function in KRAS-mutant colorectal cancer

已完结 10 由祁茵发布于 2026/4/19 19:38:48

DOI:10.1038/s42255-026-01482-3
作者：Yun Yang, Yong Wu, Xin Guo, Wen-Juan Gan, Wen-Xin Wu, Wei-Yi Shi, Xiao-Shun He, Yi-Xuan Liu, Shan Wan, Zhi Jiang, Yue Liu, Xiu-Ming Li, Zu-Da Pan, Xue Zhang, You Xu, Xiao-Jiao Gao, Ling-Chuan Guo, Gui
文献类型：期刊论文
补充材料：只需要正文

Nature

Abstract：Kirsten rat sarcoma (KRAS) mutations are key drivers of oncogenesis and therapy resistance in colorectal cancer (CRC), yet the underlying molecular mechanisms and effective targeted therapie

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