Quantification of total and conjugated antibody of a novel ADC in rat by two affinity-capture LC-MS/MS methods using a single surrogate peptide

已完结 20 由 honey 发布于 2026/4/21 12:54:26

DOI:10.1016/j.jchromb.2026.125031
作者：Pingping Yin , Tingting Liu , Yimin Tao , Jinchuan Hong , Qiuping Qin , Likun Gong
文献类型：期刊论文
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Elsevier

Abstract：GL-2401 is a novel antibody-drug conjugate (ADC) made by site-specific enzymatic conjugation of monomethyl auristatin E (MMAE) to trastuzumab at the N297 glycosylation site. We aimed to deve

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