Integrating synthesis, pharmacological evaluation, and molecular dynamics simulation of novel 8-substituted theophylline hybrids as potential PDE-4B inhibitors, bronchodilators and antibacterial

已完结 20 由 honey 发布于 2026/4/21 11:58:27

DOI:10.1016/j.bioorg.2026.109591
作者：Taha F.S. Ali , Marina A.O. Yani , Ibrahim M. Salem , Hend Mamdoh , Mohamed F. Radwan , Tarek S. Ibrahim , Eman A.M. Beshr , Alaa M. Hayallah
文献类型：期刊论文
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Elsevier

Abstract：Methylxanthines, particularly theophylline, have long served as effective bronchodilators for severe asthma. Emerging evidence links bacterial infection to asthma pathogenesis, motivating th

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