Amino acid supplementation enhances in vivo efficacy of lipid nanoparticle–mediated mRNA delivery in preclinical models

已完结 10 由 bobobo 发布于 2026/4/20 21:35:05

DOI:10.1126/scitranslmed.adx4097
作者：Kangfu Chen,?Wenhan Wang,?Amber Lennon,?Ryan A. McClure,?Aleksandra Vuchkovska,?Shana O. Kelley,?Zongjie Wang
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Lipid nanoparticles (LNPs) play a critical role in the delivery of therapeutic messenger RNA (mRNA). Despite extensive efforts to optimize lipid formulations for in vivo delivery, efficacy o

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