Preparation of targeted lipid nanoparticles for precision nucleic acid delivery.

已完结 10 由 Faye 发布于 2026/5/17 9:55:08

DOI:10.1038/s41596-025-01330-w
作者：Hannah C Geisler, Elisa Battistini, Ajay S Thatte, Marshall S Padilla, Michael J Mitchell
文献类型：期刊论文
补充材料：只需要正文

Nature

Abstract：Intravenous administration of lipid nanoparticles for the delivery of nucleic acid therapeutics remains constrained by passive uptake mechanisms in the liver, often necessitating high doses

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