Discovery and Structural Optimization of Novel 2-Aminopyrimidine Derivatives as Potent and Selective IKKβ Inhibitors for the Treatment of Colorectal Cancer

已完结 10 由肝论文的秃头小白发布于 2026/10/13 19:56:00

DOI:10.1021/acs.jmedchem.5c01938
作者：Kun Wang,?, ,?Yina Hu,?, ,?Peng Liu,?, ,?Changgui Shi,?, ,?Jinke Yuan,?, ,?Youshuo Zang,?, ,?Yeying He,?, ,?Bin Li,?, ,?Jiahao Zheng,?, ,?Jiaying Tong,?, ,?Chaoyue Chen,?, ,?Lehao Huang,?, ,?Fangjun Z
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：The IκB kinase β (IKKβ)-mediated NF-κB signaling pathway plays a critical role in colorectal cancer progression. We designed and synthesized a novel series of 2-aminopyrimidine derivatives a

应助信息

2小时前

iwu

44a5ff5cc70511f1914334735aa3bc31.pdf 已采纳

3小时前

Book学术机器人

2026/10/13 19:56:00 未找到该文献，机器人已退出，请等待人工下载

2026/10/13 19:56:00 Book学术AI机器人收到请求，开始寻找文献

2026/10/13 19:56:00 已向机器人发送请求

3小时前

肝论文的秃头小白发布求助

上一个求助:其它数据库Naturally Fractured Carbonate Reservoir Characterization: A Case Study of a Mature High-Pour Point Oil Field in Hungary 下一个求助:ElsevierDesign, synthesis, and biological evaluation of Flavokavain B derivatives as potent TRF2 inhibitors for the treatment of Osteosarcoma