Influence of Trp-Cage on the Function and Stability of GLP-1R Agonist Exenatide Derivatives

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DOI:10.1021/acs.jmedchem.4c01553
作者：Dániel Horváth, Pál Stráner, Nóra Taricska, Zsolt Fazekas, Dóra K. Menyhárd, András Perczel
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Exenatide (Ex4), a GLP-1 incretin mimetic polypeptide, is an effective therapeutic agent against diabetes and obesity. We highlight the indirect role of Ex4’s structure-stabilizing Trp-cage

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