Optimization of lipid nanoparticles reduces hepatic accumulation and enhances local delivery of mRNA.

已完结 10 由 sailor 发布于 2026/10/21 16:14:22

DOI:10.1007/s11427-025-3541-0
作者：Yue Ma,?Yaoxian Han,?Jiawei Zhou,?Yuxin Xiao,?Jie Liu,?Wenjie Sun,?Hui Yang,?Guangyu Hu,?Shangang Li,?Weizhi Ji,?Wenting Guo,?Lei Zhang,?Yongchang Chen
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1007/s11427-025-3541-0

Springer

Abstract：Lipid nanoparticles (LNPs) have emerged as the most widely used non-viral gene delivery system, particularly for mRNA therapeutics. However, predominant hepatic accumulation and poor local d

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