Discovery of Pyrazolo[1,5-a]-1,3,5-Triazine Derivatives as Potent, Highly Selective and Orally Available Macrocyclic CDK7 Inhibitors

已取消 10 由石头发布于 2026/10/21 15:21:08

DOI:10.1021/acs.jmedchem.6c01660
作者：Quanpeng Wei,Yanxin Tao,Xinpeng Ning,Suyun Jia,Yan Chen,Xiaoli Du,Xinyu Sun,Lingrui Xu,Xinrui Jiang,Pengpeng Niu,Mengyang Fan,Yupeng Li,Dawei Ma,Shan Li,Ke Ding
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：Cyclin-dependent kinase 7 (CDK7) is a promising cancer therapeutic target due to its dual role in cell cycle progression and gene transcription. However, current CDK7 inhibitors generally ex

应助信息

2026-10-21

Book学术机器人

2026/10/21 15:21:08 未找到该文献，机器人已退出，请等待人工下载

2026/10/21 15:21:08 Book学术AI机器人收到请求，开始寻找文献

2026/10/21 15:21:08 已向机器人发送请求

2026-10-21

石头发布求助

上一个求助:其它数据库Naturally Fractured Carbonate Reservoir Characterization: A Case Study of a Mature High-Pour Point Oil Field in Hungary 下一个求助:Royal Society of Chemistry (RSC)Fine-tuning the molecular conformation and packing structures of coumarin-based luminogens to achieve distinct piezochromic properties upon mechanical grinding and under hydrostatic pressures?