Development of a Flow Process to tert-Butyl 4-(6-Chloropyridin-2-yl)piperidine-1-carboxylate

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DOI:10.1021/acs.oprd.5c00467
作者：Aaron F. Baldwin,?, ,?Nga M. Do,?, ,?Xican He,?, ,?Craig J. Knight,?, ,?Taegyo Lee,?, ,?Bin Liu,?, ,?Mark Duane McLaws,?, ,?Philip Peach,?, ,?Angela L. A. Puchlopek-Dermenci,?, ,?Rachel Ruest,?, ,?Ste
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American Chemical Society (ACS)

Abstract：This paper outlines the development of a continuous manufacturing process for producing the key compound tert-butyl 4-(6-chloropyridin-2-yl)piperidine-1-carboxylate. A 3-step process, perfor

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