An Inhibitor-in-Pieces Approach to DAHP Synthase Inhibition: Potent Enzyme and Bacterial Growth Inhibition

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DOI:10.1021/acsinfecdis.1c00462
作者：Maren Heimhalt,?Pallavi Mukherjee,?Ryan A. Grainger,?Robert Szabla,?Christopher Brown,?Rebecca Turner,?Murray S. Junop,?Paul J. Berti*
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) synthase catalyzes the first step in the shikimate biosynthetic pathway and is an antimicrobial target. We used an inhibitor-in-pieces appro

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