Discovery of a Potent, Selective, and Orally Efficacious STAT6 PROTAC for the Treatment of Atopic Dermatitis

已完结 20 由 leek 发布于 2026/9/28 11:09:01

DOI:10.1021/acs.jmedchem.6c01208
作者：Wentao Wang,Mengyu Zhao,Liuzhi Hu,Chenxi Wang,Zheyuan Shen,Rongkuan Jiang,Feifei Peng,Yuxuan Wang,Jinxin Che,Wenhai Huang,Mingfei Wu,Xiaowu Dong
文献类型：期刊论文
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Abstract：Abstract Signal transducer and activator of transcription 6 (STAT6), a key mediator of IL-4/IL-13 signaling, regulates Th2 differentiation, making it an attractive target for atopic dermatit

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