Optimization of Indole- and Pyrazole-fused Glycyrrhetinic Acid Derivatives as Potent PTP1B Inhibitors: In Silico, In Vitro, In Vivo, and Metabolomic Studies

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DOI:10.1021/acsbiomedchemau.5c00164
作者：Mitzi Lo?pez-Sa?nchez,?Hannya Mendoza-Mota,?Ledy De-la-Cruz-Marti?nez,?Fe?lix Matadamas-Marti?nez,?Diana Laura Torres-Chaco?n,?Rosendo Marti?nez-Arellano,?Juan Francisco Palacios-Espinosa,?Jaime Pe?re
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Protein tyrosine phosphatase 1B (PTP1B) is a crucial enzyme involved in regulating insulin and leptin signaling pathways, making it a promising target for treating type 2 diabetes. In thi

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