Asymmetric Synthesis of Chiral δ-Caprolactams: Access to a Key Intermediate of Ubrogepant

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DOI:10.1021/acs.joc.6c01034
作者：Qingyuan Shi,?Yuhuan Zhang,?Xuan Chen,?Junjie Zhu,?Junjie Zhao,?Chuanyi Xing,?Fei Li,?Dongyin Chen
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Chiral δ-caprolactam constitutes the key pharmacophore of Calcitonin gene-related peptide receptor antagonists such as ubrogepant and atogepant, and its synthesis is quite challenging. He

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