BASIC Enables Selection-Free Efficient Knock-In of Large DNA in Primary Human T Cells

已取消 10 由 123 发布于 2026/9/29 14:59:59

DOI:10.1016/j.ymthe.2025.12.064
作者：Kexin Wang, Xiaorui Li, Jin Li, Zhuoying Yu, Pan Li, Yuyang Xie, Jinxin Liu, Honglin Huang, Shanshan Zhang, Mengqiao Zhang, Wenju Ma, Fei Gao, Xuguang Du, Jianxun Wang, Mario R. Capecchi, Sen Wu
文献类型：期刊论文
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Elsevier

Abstract：Efficient and precise insertion of large DNA fragments into primary human T cells has remained a bottleneck for gene and cell therapy. We present BASIC, a modular platform that combines BaEV

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