Assessment of Stereochemical Comparability in Phosphorothioated Oligonucleotides by CD, 31P NMR, and NP1 Digestion Coupled to LC-MS

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DOI:10.1021/acs.analchem.4c06140
作者：Nicholas R. Larson, Fei Tong, Zifan Li, Yueheng Zhang, Li Xiao, Xuan Zhou, Jonas P. Immel-Brown, George M. Bou-Assaf
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Substitution of a nonbridging oxygen for sulfur on the phosphodiester backbone of an oligonucleotide enhances its pharmacokinetic properties. This substitution creates a new chiral center at

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