Sequential digestions enable identification and quantification of rapid aspartic acid isomerization in the CDR of a monoclonal antibody light chain

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DOI:10.1016/j.jpba.2026.117383
作者：Jér?me Jonveaux,?Marc Faudon,?Pauline Heymes,?Valentina Lucchini,?Maria Fernanda Zuluaga Estrada,?Michael Jahn,?Mostafa Zarei
文献类型：期刊论文
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Elsevier

Abstract：Isomerization of aspartic acid (Asp) to isoaspartic acid (isoAsp) within the complementarity-determining regions (CDRs) of monoclonal antibodies (mAbs) can lead to conformational changes tha

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