Maternal sleep deprivation reshapes offspring hippocampal development through a Trem2-centered microglial program revealed by single-nucleus and spatial transcriptomics

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DOI:10.1038/s41380-026-03831-w
作者：Xiaobin Wu, Liuqing Yang, Yepeng Fan, Xiaohuan Li, Xiuyu Shi, Chunfang Dai, Yayan Pang, Jiaojiao Wang, Yupeng Cun, Zhifang Dong
文献类型：期刊论文
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Nature

Abstract：Maternal sleep deprivation during late pregnancy is common and has been linked to increased neuropsychiatric risk in offspring, but the mechanisms by which it shapes developing hippocampal c

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