Discovery and Characterization of RP04340: A Highly Potent and Orally Active Pan-KRAS PROTAC Degrader

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DOI:10.1021/acs.jmedchem.6c01832
作者：Xiang Ji,?Yuening Du,?Qiguo Zhang,?Bin Zong,?Kang Du,?Xiaolin He,?Gang Wu,?Chao Liang,?Qingyao Hu,?Yuwei Zhang,?Huanping Li,?Liqiang Shen,?Zijun Chen,?Bing Bai,?Lin Wang,?Jinchao Ai,?Leduo Zhang,?Hong
文献类型：期刊论文
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Abstract：Targeting diverse KRAS mutations with a single agent remains a significant challenge in oncology. Here, we report the discovery and characterization of RP04340, a potent and orally bioava

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