Targeting KRAS mutations: orchestrating cancer evolution and therapeutic challenges

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DOI:10.1038/s41392-025-02473-8
作者：Khalil Choucair, Hafsa Imtiaz, Md Hafiz Uddin, Misako Nagasaka, Mohammad Najeeb Al-Hallak, Philip A. Philip, Bassel El-Rayes, Boris C. Pasche, Asfar S. Azmi
文献类型：期刊论文
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Nature

Abstract：Activating KRAS mutations are highly relevant to various cancers, and KRAS is the most frequently altered oncogenic protein in solid tumors. While historically considered undruggable, two KR

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