Structure-activity relationship study of a series of nucleoside derivatives bearing sulfonamide scaffold as potent and selective PRMT5 inhibitors

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DOI:10.1016/j.bioorg.2022.106228
作者：Yuting Chen , Qiongyu Shi , Hong Yang , Jiayi Li , Kaixin Zhou , Junjie Zhang , Zekun Wang , Huanyu Shi , Bing Xiong , Jia Liu , Xun Huang , Tong
文献类型：期刊论文
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Elsevier

Abstract：Protein arginine methyltransferase 5 (PRMT5) is a promising target for the treatment of malignant tumors. The discovery of nucleoside-derived inhibitors against PRMT5 with novel scaffold has

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