One stone two birds: Introducing piperazine into a series of nucleoside derivatives as potent and selective PRMT5 inhibitors

已完结 10 由探索者发布于 2026/10/12 11:09:59

DOI:10.1016/j.ejmech.2024.116970
作者：Huaxuan Li , Hong Yang , Li Liu , Jiahong Zheng , Qiongyu Shi , Bang Li , Xingcan Wang , Ying Zhang , Ruilin Zhou , Jian Zhang , Zhong-Zhu Chen ,&nbsp
文献类型：期刊论文
补充材料：只需要正文

Elsevier

Abstract：The protein arginine methyltransferase 5 (PRMT5) has emerged as potential target for the treatment of cancer. Many efforts have been made to develop potent and selective PRMT5 inhibitors tar

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