Unanticipated Quinoline Modification on Vancomycin as an Effective Strategy to Alter the Antibacterial Profile and Combat Multidrug Resistance

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DOI:10.1021/jacs.5c14268
作者：Taopeng Chang,&nbsp;, ,&nbsp;Zhifu Chen,&nbsp;, ,&nbsp;Lishu Sheng,&nbsp;, ,&nbsp;Xiaolei Bian,&nbsp;, ,&nbsp;Peng He,&nbsp;, ,&nbsp;Xiao He,&nbsp;, ,&n
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Lipid II, referred to as the bacterial “Achilles’ heel” and serving as the target of vancomycin, remains inaccessible to vancomycin in Gram-negative bacteria due to their outer membrane (OM)

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