Customizing CRISPR–Cas PAM specificity with protein language models

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DOI:10.1038/s41587-025-02995-0
作者：Stephen Nayfach, Aadyot Bhatnagar, Andrey Novichkov, Nahye Kim, Alexander M. Hoffnagle, Riffat Hussain, Gabriella O. Estevam, Emily Hill, Jeffrey A. Ruffolo, Rachel A. Silverstein, Joseph Gallagher, B
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Nature

Abstract：CRISPR–Cas enzymes must recognize a protospacer-adjacent motif (PAM) to edit a genomic site, greatly limiting the range of targetable sequences in a genome. Although engineering strategies t

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