One-Pot Assembly of Dual-Site-Specific Antibody–Drug Conjugates via Glycan Remodeling and Affinity-Directed Traceless Conjugation

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DOI:10.1021/acs.bioconjchem.3c00048
作者：Caihong Tang,?Yue Zeng,?Jianxin Zhang,?Xing Zheng,?Feng Tang,?Xu Yao*,?Zhong-Xing Jiang*,?Wei Shi* and Wei Huang*,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：The drug-to-antibody ratio (DAR) value and dual-drug combination greatly influence the therapeutic index of antibody–drug conjugates (ADCs). The reported approaches usually require multifunc

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