Trans-splicing denoiser circuits enable highly sensitive cellular sensors for physiological biomarkers

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DOI:10.1016/j.bios.2025.117709
作者：Sheng-Yan Chen ,?Yuanli Gao ,?Yi Fan ,?Yuwei Pan ,?Nan Zhou ,?Baojun Wang
文献类型：期刊论文
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Elsevier

Abstract：Whole-cell biosensors face critical limitations in physiological biomarker detection, including limited dynamic range, suboptimal sensitivity, and reliance on specialized instrumentation. He

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