Design and discovery of highly potent lysine 27 of histone H3 (H3K27) demethylase inhibitors for the treatment of inflammatory bowel disease

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DOI:10.1016/j.ejmech.2026.119389
作者：Yuqi Tang, Xin Hu, Ancheng Shen, Qinghua Wang, Zilan Song, Wantao Chen, Xu Wang
文献类型：期刊论文
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Elsevier

Abstract：Lysine specific demethylase 6A/B (KDM6A/B), histone lysine demethylases targeting H3K27me3, have emerged as key regulators of inflammatory gene expression and are increasingly implicated in

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