IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing antitumor efficacy

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DOI:10.1016/j.immuni.2025.10.021
作者：Sofía Castelli, Wesley V. Wilson, Ugur Uslu, Amanda V. Finck, Philipp C. Rommel, Charles-Antoine Assenmacher, Sebastian J. Atoche, Mikko Siurala, M. Angela Aznar, Regina M. Young, Carl H. June
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Elsevier

Abstract：The success of chimeric antigen receptor (CAR) T cell therapies targeting solid tumors is limited by the immunosuppressive tumor microenvironment. We demonstrate that endowing CAR T cells wi

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