Aging-associated HELIOS deficiency in naive CD4+ T cells alters chromatin remodeling and promotes effector cell responses

求助中 10 由大湖发布于 2026/11/14 9:57:55

DOI:10.1038/s41590-022-01369-x
作者：Huimin Zhang, Rohit R. Jadhav, Wenqiang Cao, Isabel N. Goronzy, Tuantuan V. Zhao, Jun Jin, Shozo Ohtsuki, Zhaolan Hu, Jose Morales, William J. Greenleaf,&n
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1038/s41590-022-01369-x

Nature

Abstract：Immune aging combines cellular defects in adaptive immunity with the activation of pathways causing a low-inflammatory state. Here we examined the influence of age on the kinetic changes in

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